Now since you have planned 2 days per real day (I believe that's what you have it as currently, and that it's subject to change.)
Why not have it so "colds" and fevers, exhaustion, ect. exist?
Depending on the problem, the length would be different.
Exhaustion could be cured just by not doing anything, logging out(for awhile), drinking tea and other not strenuous activities. Just sit around for awhile, read a book, hang out in the shops or talk to the npcs and talk to other people.
Colds would just be the run-of-the-mill sickness, some sneezing, coughing, other light symptoms. It doesn't really hinder you but taking some medicine and getting some rest(Logging out or in game rest.) should get rid of it.
In order to get a cold you'd have to hang out in the rain for a long time and (if possible in game) change wet clothes once out of the rain, either that or stay out during the winter in skimpy clothes.
Fevers would be heightened colds, if you didn't treat them while they were just runny noses and coughs, now it's problematic. The fever weakens you, you'll get exhausted a lot quicker, have all the fun "benefits" of before, and maybe even faint!(If possible) Npcs will say you don't look so well and actually not let you do quests in fear of your health, doctor/health npcs or just really kind npcs(People you have a high friendship with) may give you free medicine as well.
All you could really do with a fever would be the light tiers in the jobs, like watering(A few) plants and picking up lighter things like flowers and butterflies/crickets/ladybugs.
And if going to the bathroom is a thing in PO, you'd probably have to use that a lot too!
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